Leicester Tigers prop Ellis Genge will make his second international start after retaining his place in England's team to play Argentina in the second and final Test.
Kick-off in Santa Fe on Saturday is at 8.15pm BST and the game is live on BBC 2.
Fly-half George Ford, who will move to Tigers for next season, starts at fly-half after scoring 23 points in a brilliant first Test performance that helped England to a thrilling 38-34 victory.
Head coach Eddie Jones has made three changes to the starting line-up. Chris Robshaw (Harlequins) returns to the back row after recovering from an ankle injury, Sam Underhill (Bath Rugby) will make his debut at openside flanker and Piers Francis (Northampton Saints) will start at inside centre. Mark Wilson (Newcastle Falcons) and Alex Lozowski (Saracens) move to the bench.
Jones said: “We know we will need to improve our performance from last weekend if we are going to win on Saturday but we have prepared in detail and intensely this week.
“Argentina will be a much better and stronger side than last weekend so the message to the guys all week has been; it’s up to us to raise our levels.
“Despite missing 30 players on this tour, we set out to win the series 2-0. It would be a fantastic achievement for this young and talented squad to do that. On Saturday we want to finish the season and the halfway point of a four-year World Cup programme on a real high.”
England squad to play Argentina
15 Mike Brown, vc (Harlequins, 61 caps)
14 Marland Yarde (Harlequins, 12 caps)
13 Henry Slade (Exeter Chiefs, 6 caps)
12 Piers Francis (Northampton Saints, 1 cap)
11 Jonny May (Gloucester Rugby, 26 caps)
10 George Ford, vc (Bath Rugby, 36 caps)
9 Danny Care, vc (Harlequins, 72 caps)
1 Ellis Genge (Leicester Tigers, 2 caps)
2 Dylan Hartley, c (Northampton Saints, 85 caps)
3 Harry Williams (Exeter Chiefs, 1 cap)
4 Charlie Ewels (Bath Rugby, 4 caps)
5 Joe Launchbury (Wasps, 43 caps)
6 Chris Robshaw (Harlequins 55 caps)
7 Sam Underhill (Bath Rugby, uncapped)
8 Nathan Hughes (Wasps, 9 caps)
Replacements
16 Jack Singleton (Worcester Warriors, uncapped)
17 Matt Mullan (Wasps, 16 caps)
18 Will Collier (Harlequins, 1 cap)
19 Nick Isiekwe (Saracens, 1 cap)
20 Mark Wilson (Newcastle Falcons, 1 cap)
21 Jack Maunder (Exeter Chiefs, 1 cap)
22 Alex Lozowski (Saracens, 1 cap)
23 Denny Solomona (Sale Sharks, 1 cap)
Kick-off in Santa Fe on Saturday is at 8.15pm BST and the game is live on BBC 2.
Fly-half George Ford, who will move to Tigers for next season, starts at fly-half after scoring 23 points in a brilliant first Test performance that helped England to a thrilling 38-34 victory.
Head coach Eddie Jones has made three changes to the starting line-up. Chris Robshaw (Harlequins) returns to the back row after recovering from an ankle injury, Sam Underhill (Bath Rugby) will make his debut at openside flanker and Piers Francis (Northampton Saints) will start at inside centre. Mark Wilson (Newcastle Falcons) and Alex Lozowski (Saracens) move to the bench.
Jones said: “We know we will need to improve our performance from last weekend if we are going to win on Saturday but we have prepared in detail and intensely this week.
“Argentina will be a much better and stronger side than last weekend so the message to the guys all week has been; it’s up to us to raise our levels.
“Despite missing 30 players on this tour, we set out to win the series 2-0. It would be a fantastic achievement for this young and talented squad to do that. On Saturday we want to finish the season and the halfway point of a four-year World Cup programme on a real high.”
England squad to play Argentina
15 Mike Brown, vc (Harlequins, 61 caps)
14 Marland Yarde (Harlequins, 12 caps)
13 Henry Slade (Exeter Chiefs, 6 caps)
12 Piers Francis (Northampton Saints, 1 cap)
11 Jonny May (Gloucester Rugby, 26 caps)
10 George Ford, vc (Bath Rugby, 36 caps)
9 Danny Care, vc (Harlequins, 72 caps)
1 Ellis Genge (Leicester Tigers, 2 caps)
2 Dylan Hartley, c (Northampton Saints, 85 caps)
3 Harry Williams (Exeter Chiefs, 1 cap)
4 Charlie Ewels (Bath Rugby, 4 caps)
5 Joe Launchbury (Wasps, 43 caps)
6 Chris Robshaw (Harlequins 55 caps)
7 Sam Underhill (Bath Rugby, uncapped)
8 Nathan Hughes (Wasps, 9 caps)
Replacements
16 Jack Singleton (Worcester Warriors, uncapped)
17 Matt Mullan (Wasps, 16 caps)
18 Will Collier (Harlequins, 1 cap)
19 Nick Isiekwe (Saracens, 1 cap)
20 Mark Wilson (Newcastle Falcons, 1 cap)
21 Jack Maunder (Exeter Chiefs, 1 cap)
22 Alex Lozowski (Saracens, 1 cap)
23 Denny Solomona (Sale Sharks, 1 cap)
