Team manager Martin Johnson has made two changes to the XV with Mike Tindall replacing Jamie Noon at centre and Joe Worsley starting in the back row instead of Steffon Armitage.
Flood is joined on the bench by London Irish scrum-half Paul Hodgson and Gloucester back rower Luke Narraway in two further changes from the 22 that kicked off this season’s Championship with a win over Italy.
England team (v Wales, away, Saturday 5.30pm:
15 Delon Armitage (London Irish)
14 Paul Sackey (London Wasps)
13 Mike Tindall (Gloucester Rugby)
12 Riki Flutey (London Wasps)
11 Mark Cueto (Sale Sharks)
10 Andy Goode (Brive)
9 Harry Ellis (Leicester Tigers)
1 Andrew Sheridan (Sale Sharks)
2 Lee Mears (Bath Rugby)
3 Phil Vickery (London Wasps)
4 Steve Borthwick (Saracens, captain)
5 Nick Kennedy (London Irish)
6 James Haskell (London Wasps)
7 Joe Worsley (London Wasps)
8 Nick Easter (Harlequins)
Replacements
16 Dylan Hartley (Northampton Saints)
17 Julian White (Leicester Tigers)
18 Tom Croft (Leicester Tigers)
19 Luke Narraway (Gloucester Rugby)
20 Paul Hodgson (London Irish)
21 Toby Flood (Leicester Tigers)
22 Mathew Tait (Sale Sharks)
