Handrè Pollard will start at fly-half for South Africa in their Rugby Championship game against New Zealand at Ellis Park in week two of the 2022 tournament.
The soon-to-be Leicester Tigers senior squad member scored 16 points in the Springboks' opening round win over the All Blacks.
Future clubmate Jasper Wiese, who was a force up front for South Africa in last weekend's win, moves to the bench for Saturday's game in Johannesburg.
Tigers hooker Julián Montoya captains Argentina in their fixture against Australia in San Juan.
