Leicester Tigers quintet Ellis Genge, Freddie Steward, Ollie Chessum, Ben Youngs and George Ford have been included in England's matchday squad for their Six Nations game away to Italy on Sunday.
Genge and Steward start, while Chessum, Youngs and Ford have been included among the replacements.
If used off the bench, Chessum will make his Test debut.
Speaking ahead of the Test, England head coach Eddie Jones said: “We’ve set ourselves the target of playing really well and lighting up Rome.
“We’ve made some changes and this is the best side to face Italy. We want to start fast and take the game to them.
“They can be a dangerous team and have some very good players in the likes of Garbisi, Negri and Lamaro
“It’s been a difficult week, but the players have bounced back well, trained hard and are ready to put on a good performance on Sunday.”
ENGLAND XV
15. Freddie Steward (Leicester Tigers, 6 caps)
14. Max Malins (Saracens, 11 caps)
13. Joe Marchant (Harlequins, 8 caps)
12. Henry Slade (Exeter Chiefs, 44 caps) (VC)
11. Jack Nowell (Exeter Chiefs, 35 caps)
10. Marcus Smith (Harlequins, 6 caps)
9. Harry Randall (Bristol Bears, 2 caps)
1. Ellis Genge (Leicester Tigers, 32 caps) (VC)
2. Jamie George (Saracens, 62 caps)
3. Will Stuart (Bath Rugby, 16 caps)
4. Charlie Ewels (Bath Rugby, 27 caps)
5. Nick Isiekwe (Saracens, 4 caps)
6. Maro Itoje (Saracens, 52 caps)
7. Tom Curry (Sale Sharks, 37 caps) (C)
8. Alex Dombrandt (Harlequins, 5 caps)
FINISHERS
16. Luke Cowan-Dickie (Exeter Chiefs, 32 caps) (VC)
17. Joe Marler (Harlequins, 75 caps)
18. Kyle Sinckler (Bristol Bears, 48 caps)
19. Ollie Chessum (Leicester Tigers, uncapped)
20. Sam Simmonds (Exeter Chiefs, 10 caps)
21. Ben Youngs (Leicester Tigers, 113 caps)
22. George Ford (Leicester Tigers, 78 caps)
23. Elliot Daly (Saracens, 53 caps)
