Allen, the Tigers Players’ Player of the Year, sat out the match against Gloucester last week but returns to partner Manu Tuilagi at centre.
Matt Smith also returns to the starting line-up, with Jeremy Staunton and James Grindal named at half-back as Toby Flood and Ben Youngs are resting injuries.
Marcos Ayerza and George Chuter return to the front row, Ed Slater comes into the second row and captain Craig Newby returns at openside.
Jordan Crane, Louis Deacon and Steve Mafi are ruled out by injury this week.
Director of rugby Richard Cockerill said: “A couple of the guys have been nursing little niggling injuries and we have to look after ones like Toby and Ben who have played a lot of rugby recently, as we did with Craig Newby and Anth Allen last week.
“Newcastle is a tough trip but we have been very consistent through the season and we want to maintain those high standards.”
Leicester Tigers (v Newcastle Falcons, away, Friday 6pm)
15 Scott Hamilton
14 Matt Smith
13 Manu Tuilagi
12 Anthony Allen
11 Alesana Tuilagi
10 Jeremy Staunton
9 James Grindal
1 Marcos Ayerza
2 George Chuter
3 Martin Castrogiovanni
4 Ed Slater
5 George Skivington
6 Tom Croft
7 Craig Newby (c)
8 Thomas Waldrom
Replacements
16 Rob Hawkins
17 Boris Stankovich
18 Dan Cole
19 Calum Green
20 Ben Woods
21 Sam Harrison
22 Billy Twelvetrees
23 Horacio Agulla
Newcastle Falcons: 15 Tom Catterick, 14 Alex Tait, 13 Rob Vickerman, 12 Tane Tu'ipulotu, 11 Luke Fielden, 10 Jimmy Gopperth (c), 9 Chris Pilgrim; 1 Jonny Golding, 2 Matt Thompson, 3 Euan Murray, 4 Filipo Levi, 5 Andrew van der Heijden, 6 Mark Wilson, 7 Will Welch, 8 Ally Hogg. Replacements: 16 Rob Vickers, 17 Grant Shiells, 18 Kieran Brookes, 19 Tim Swinson, 20 Alex Gray, 21 Micky Young, 22 Luke Eves, 23 Gcobani Bobo
