Kyle Eastmond has been ruled out by illness of the Gallagher Premiership opener away to Worcester Warriors on Saturday (October 19) afternoon at Sixways Stadium.
The international's absence sees Tom Hardwick come in to Tigers starting side at inside-centre and Andy Forsyth added to the bench.
Forsyth's inclusion means the Tigers Academy graduate is in line to play his first Premiership fixture for the club in almost seven years after re-joining Leicester over the summer on loan from Championship club Coventry.
Leicester Tigers (v Worcester Warriors, Sixways, Saturday 3.00pm)
15 George Worth
14 Adam Thompstone
13 EW Viljoen
12 Tom Hardwick
11 Jonah Holmes
10 Noel Reid
9 Ben White
1 Greg Bateman
2 Tom Youngs (c)
4 Will Spencer
5 Calum Green
8 Guy Thompson
Replacements
16 Jake Kerr
17 Facundo Gigena
19 Harry Wells
20 Jordan Coghlan
21 Sam Harrison
22 Andy Forsyth
23 Jordan Olowofela