Tuilagi was on loan at the Yorkshire club last season before sealing a summer move from Tigers.
Director of rugby Stuart Lancaster has recalled prop Mike MacDonald and hooker Vili Ma'asi after injury, and there is a place in the back row for Rhys Oakley who starts at No8. Calum Clark moves across to flanker in place of Martin Schusterman.
Jon Dunbar is named among the replacements after being sidelined by a hamstring injury since the second game of the season. Fosi Pala'amo and James Parkes drop to the bench after starting last weekend's European Challenge Cup win over Dax.
Leeds Carnegie team:
15 Leigh Hinton
14 Apo Satala
13 Rob Vickerman
12 Andy Tuilagi
11 Tom Biggs
10 Alberto Di Bernardo
9 Joe Bedford
1 Mike MacDonald
2 Vili Ma'asi
3 Colin Noon
4 Stuart Hooper
5 Erik Lund
6 Danny Paul
7 Calum Clark
8 Rhys Oakley
Replacements
16 Fosi Pala'amo
17 James Parkes
18 Pablo Bouza
19 Jon Dunbar
20 Darren Edwards
21 Lee Blackett
22 Jonny Hepworth
