England international George Chuter starts in the front row, while Johne Murphy and Ben Herring return after injuries ruled out Matt Smith and Marco Wentzel.
Dan Hipkiss, a try-scorer in the win at Bristol last Friday, makes his 100th appearance for the club, lining up alongside skipper Aaron Mauger at centre.
The replacements include young forwards Calum Green and Dan Hemingway as well as senior internationals Mefin Davies, Derick Hougaard and Tom Varndell.
Harry Ellis, Toby Flood, Tom Croft, Julian White, Martin Castrogiovanni and Geordan Murphy are on international duty at the RBS 6 Nations.
Benjamin Kayser (neck), Matt Smith (ankle), Marco Wentzel (knee), Jordan Crane (knee), Brett Deacon (foot), Seru Rabeni (knee), Lewis Moody (ankle), Richard Blaze (foot) and Craig Newby (hamstring) are sidelined by injury. Martin Corry is unavailable due to suspension.
Tickets for Saturday’s game are still available from the Tigers ticket office. Call 08701 28 34 30, book online at www.leicestertigers.com or call in at Welford Road.
Leicester Tigers (v Saracens, Welford Road, Saturday 2.45pm)
15 Scott Hamilton
14 Johne Murphy
13 Dan Hipkiss
12 Aaron Mauger (c)
11 Alesana Tuilagi
10 Sam Vesty
9 Julien Dupuy
1 Marcos Ayerza
2 George Chuter
3 Dan Cole
4 Louis Deacon
5 Ben Kay
6 Ben Woods
7 Ben Herring
8 Ben Pienaar
Replacements
16 Mefin Davies
17 Boris Stankovich
18 Calum Green
19 Dan Hemingway
20 Ben Youngs
21 Derick Hougaard
22 Tom Varndell
