The 20-year-old Tuilagi resumes after suffering a cheek injury in his first club appearance of the season in the LV= Cup win over Gloucester during October, while Croft sat out last weekend’s league win over Northampton Saints.
Croft joins Julian Salvi and Thomas Waldrom in the back row, while Tuilagi is named alongside Matt Smith at centre.
The only other change to the starting line-up line-up sees Martin Castrogiovanni named at tighthead prop, with Dan Cole among the replacements.
Steve Mafi and Billy Twelvetrees, who both started the Aviva Premiership Rugby win over Northampton, are also among the replacements.
Tigers top Pool 4 after wins in the opening two rounds against Aironi away and Ulster at home.
Clermont make the return trip to Welford Road next Saturday (December 17). Kick-off is at 1.30pm and tickets are available now from the Tigers ticket office (open 8.30am-5pn weekdays, until 8pm Wednesdays and 9am-5pm Saturdays) and from the Club Store in Market Street, Leicester. Or book online any time by clicking here.
Leicester Tigers (v ASM Clermont Auvergne, Stade Marcel Michelin, Sunday 4pm local time, 3pm UK time)
15 Geordan Murphy (c)
14 Horacio Agulla
13 Matt Smith
12 Manu Tuilagi
11 Alesana Tuilagi
10 Toby Flood
9 Ben Youngs
1 Marcos Ayerza
2 George Chuter
3 Martin Castrogiovanni
4 Louis Deacon
5 George Skivington
6 Tom Croft
7 Julian Salvi
8 Thomas Waldrom
16 Rob Hawkins
17 Boris Stankovich
18 Dan Cole
19 Steve Mafi
20 Ed Slater
21 Sam Harrison
22 Billy Twelvetrees
23 Scott Hamilton
ASM Clermont Auvergne: 15 Lee Byrne, 14 Sitiveni Sivivatu, 13 Aurelien Rougerie, 12 Wesley Fofana, 11 Julian Malzieu, 10 Brock James, 9 Morgan Parra; 1 Lionel Faure, 2 Benjamin Kayser, 3 Davit Zirakashvili, 4 Julien Pierre, 5 Nathan Hines, 6 Gerhard Vosloo, 7 Alexandre Lapandry, 8 Julien Bonnaire. Reps: Ti’i Paulo, 17 Vincent Debaty, 18 Clement Ric, 19 Jamie Cudmore, 20 Elvis Vermeulen, 21 Kevin Senio, 22 David Skrela, 23 Regan King
